The RIRC is a basic science research facility devoted to the study of repair, regeneration, and recovery of function after spinal cord injury. Five Resident principal investigators (PI's) use rodent models (rats and mice) and related cell culture systems to explore cellular and molecular mechanisms that contribute to regeneration and cellular repair. A major focus is on enhancing the regeneration of damaged nerve fibers (axon regeneration) and on the use of stem cells for cellular replacement therapy. There are also 23 Associate PI's whose labs are located elsewhere in the University who study neural repair, regeneration, stem cell biology and human subjects research focusing on advanced functional imaging techniques, novel rehabilitative strategies including the use of robotics, and advanced prosthetics.

Scientists at the RIRC address a number of potential targets for therapy for SCI. Importantly, some of the most promising strategies, and the ones that are closest to clinical application, involve interventions during the acute post-injury period (days to weeks after the injury). However promising these strategies are, we are committed to the long-term goal of developing treatments to promote nerve regeneration and repair for individuals with chronic injuries, and this is reflected in the research programs of each PI. The full scope of the research can best be appreciated by consulting the research summaries of the individual PI's.

Here, we highlight the general themes, and provide a roadmap for navigating through the more detailed descriptions.

* Limiting secondary degeneration after spinal cord injury

 * Enhancing regeneration of damaged nerve cells

* Human Embryonic Stem cells

* Improving Motor Recovery

* Autonomic Function and Pain

* The RIRC: Promoting Collaboration and Cooperation