Publications

• Reeve-Irvine Research Center Publications 2005
• Reeve-Irvine Research Center Publications 2004
• Reeve-Irvine Research Center Publications 2003
• Reeve-Irvine Research Center Publications 2002
• Reeve-Irvine Research Center Publications 2001
• Reeve-Irvine Research Center Publications 2000

Engesser-Cesar C., Anderson A. J., Edgerton V. R., Basso M., and Cotman C. W. Voluntary wheel running improves recovery from contusion-induced spinal cord injury. 2005. Journal of Neurotrauma. 22(1): 157-171.

Anderson A. J., Najbauer J., Robert S., Huang W., and Young W. Upregulation of complement inhibitors in association with vulnerable cells following contusion-induced spinal cord injury. 2005. Journal of Neurotrauma. 22(3): 382-397.

Perreau V. M., Adlard P. A., Anderson A. J., and Cotman C. W. Oligonucleotide microarray analysis and RT-PCR validation of exercise-induced gene expression changes in the rat spinal cord. 2005. Gene Expression. 12:107-121.

Garraway S., Anderson A. J., and Mendell L. BDNF-induced facilitation of afferent evoked responses in lamina II neurons is reduced following neonatal spinal cord contusion injury. In press. Journal of Neurophysiology. n.00179.2005 (available online 05-18-05).

Cummings B. J., Uchida N., Tamaki S. J., Salazar D. L., Summers R., Gage F. H., and Anderson A. J. (2005) Human neural stem cells differentiate and promote behavioral improvements in spinal cord injured mice. Proceedings of the National Academy of Sciences, 102(39):14069–14074.

Anderson, KDD, Gunawan, A, Steward, O. (2005). Quantitative behavioral analysis of forepaw function after cervical spinal cord injury in rats: Relationship to the corticospinal tract.. Exp. Neurol. 194:161-174.

Adlard PA, Perreau VM, Cotman CW. (2005) The exercise-induced expression of BDNF within the hippocampus varies across life-span, Neurobiol Aging. Apr;26(4): 511-20.

Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW. (2005) Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats, Neurobiol Aging. May;26(5): 749-63.

Engessar-Cesar C, Anderson AJ, Basso DM, Edgerton VR, Cotman CW. (2005) Voluntary wheel running improves recovery from a moderate spinal cord injury, J Neurotrauma. Jan;22(1): 157-71..

Adlard, PA, Perreau VM, Pop V, Cotman CW. (2005). Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005 Apr 27;25(17):4217-21.

Perreau VM, Adlard PA, Anderson AJ, Cotman CW.(2005)Exercise-induced gene expression changes in the rat spinal cord. Gene Expr. 12(2):107-21.

Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. (2005) Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs.Prog Neuropsychopharmacol Biol Psychiatry. Mar;29(3):461-9.

Berchtold NC, Chinn G, Chou M, Kesslak, JP Cotman CW. (2005) Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience. May 13;

Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW. (2005) Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats, Neurobiol Aging. May;26(5): 749-63.

Cotman CW, Poon WW, Rissman RA, Blurton Jones M. (2005) The role of caspase cleavage of tau in Alzheimer disease neuropathology, J Neuropathol Exp Neurol. Feb;64(2): 104-12

Engesser-Cesar C, Anderson AJ, Basso DM, Edgerton VR, Cotman CW. (2005) Voluntary wheel running improves recovery from a moderate spinal cord injury, J Neurotrauma. Jan22(1): 157-71.

Cramer SC, Benson RR, Himes DM, Burra VC, Janowsky JS, Weinand ME, Brown JA, Lutsep HL. Use of functional MRI to guide decisions in a clinical stroke trial. Stroke; 36:e50-52.

Cramer SC, Lastra L, Michael G. Lacourse MG, Cohen MJ. Brain motor system function after complete spinal cord injury. Brain (in press).

Brewster, A.L., J. A. Bernard, C.M. Gall and T.Z. Baram 2005 Seizures promote heteromerization of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCNs) by altering the relative abundance of HCN1 and HCN2 isoforms. Neurobiol Dis. 19:200-7

Bernard, J.A., E. A. Kramár, Reidun Torp, Ching-Yi Lin, Eduardo A. Pineda, Gary Lynch, C. M. Gall 2005 Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology. J Neurochem. 93:834-849.

Lin, C-Y., G. Lynch and C.M. Gall, 2005 AMPA receptor stimulation increases 5β1 integrin surface expression, adhesive function and signaling. J. Neurochem., 94: 531-546.

Lin, B, E.A. Kramár, X. Bi, F.A. Brucher, C.M. Gall and G. Lynch 2005 Theta stimulation polymerizes actin in dendritic spines of hippocampus. J. Neurosci. 25: 2062-2069.

Rex, C.S., E.A. Kramár, L.L. Colgin, C.M. Gall, and G. Lynch. 2005 Long-Term Potentiation Is Impaired in Middle-Aged Rats: Regional Specificity and Reversal by Adenosine Receptor Antagonists. J. Neurosci. 25: 5956-5966.

Tuszynski M.H., Thal L., Pay M., Salmon D.P., U H.S., Bakay R., Patel P., Blesch A, Vahlsing H.L., Ho G., Tong G., Potkin S.G., Fallon J., Hansen L., Mufson E.J., Kordower J.H., Gall C., Conner J. 2005 A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nature Medicine 11:551-5.

Jourdi H., X. Lu, T. T. Yanagahara, J. C. Lauterborn, Xiaoning Bi, C. M. Gall and M. Baudry 2005 Prolonged positive modulation of AMPA receptors induces calpain-mediated PDZ protein degradation and AMPA receptor down-regulation in cultured hippocampal slices. JPET 314: 16-26.

Numan, S., C.M. Gall, and K.B. Serology 2005 Developmental expression of neurotrophins and their receptors in postnatal rat ventral midbrain. Molecular Neurosci., in press.

Milan Radojicic, Paul J Reier, Oswald Steward and Hans Keirstead (2005) Septations in posttraumatic syringomyelia contain axons Exp. Neurol. (in press)

Hans S. Keirstead, Giovanna Bernal, Gabriel Nistor, Minodora Totoiu, Frank Cloutier, Kelly Sharp and Oswald Steward (2005) Remyelination and locomotor recovery follows transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into acute but not chronic spinal cord injuries, J. Neurosci. 25(19): 4694-4705.

Minodora Totoiu and Hans S. Keirstead (2005) Spinal cord injury is accompanied by chronic progressive demyelination. J. Comp. Neurol. 486: 373-383.

Hans S. Keirstead, Vadim Fedulov, Frank Cloutier, Oswald Steward and Barry P. Duel (2005) A non-invasive ultrasonographic method to evaluate bladder function recovery in spinal cord injured rats Exp. Neurol. 194, (1): 120-127.

Gabriel I. Nistor, Minodora O. Totoiu, Nadia Haque, Melissa K. Carpenter and Hans S. Keirstead (2005) Differentiation of oligodendrocytes in high-purity from human embryonic stem cells. Glia 49; 385-396 (journal cover).

Caccamo, A., Oddo, S., Sugarman, M. C., Akbari, Y., and LaFerla, F. M. (2005). Age- and region-dependent alterations in β-amyloid degrading enzymes (neprilysin and insulin degrading enzyme): implications for Aβ-related disorders. Neurobio. Aging 26, 645-654.

Billings, L., Oddo, S., McGaugh, J. L., and LaFerla, F. M. (2005). Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675-688.

Oddo, S., Caccamo, A., Green, K., Liang, K., Tran, L., Chen, Y., Leslie, F. M., and LaFerla, F. M. (2005). Chronic nicotine exposure exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc. Natl. Acad. Sci., USA 102, 3046-3051.

Sugarman, M. C., Kitazawa, M., Querfurth, H., Baker, M., Caizzo, V., and LaFerla, F. M. (2005). Fast twitch muscle fibers are more vulnerable to damage and APP accumulation in IBM patients and in a transgenic model. Neurobiology of Aging, in press.

Smith, I. F., Hitt, B., Green, K. N., Oddo, S., and LaFerla, F. M. (2005). Enhanced calcium induced calcium release in the 3xTg-AD model of Alzheimer's disease. J. Neurochem. 94, 1711-1718.

Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., and LaFerla, F. M. (2005). LPS-induced inflammation exacerbates tau pathology by a cdk5-mediated pathway in a transgenic model of Alzheimer's disease. J. Neurosci. 25, in press.

Oddo, S., Caccamo, A., Smith, I. F., Green, K. N., and LaFerla, F. M. (2005). A dynamic relationship between intracellular and extracellular pools of Aβ. American Journal of Pathology, in press.

Steward, O., Zheng, B., and Tessier-Lavigne, M. (in press) False resurrections: Distinguishing regenerated from spared axons in the injured CNS. Commentary, J. Comp. Neurol.

Gupta, R., and Steward, O. (in press) Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J. Comp. Neurol.

Temple, M.D., and Steward, O. (in press) Visualizing changes in circuit activity resulting from denervation and reinnervation using immediate early gene expression. J. Neurosci.

Sullivan, P.G., Dube, C., Dorembos, K., Steward, O., and Baram, T.Z. (in press) Mitochondrial uncoupling protein-2 contributes crucially to the resistance of immature brain to excitotoxic neuronal death. Ann. Neurol.

Zheng, B. Ho, C., Keirstead, H., Steward, O. and Tessier-Lavigne, M. (provisionally accepted pending revision) Lack of enhanced spinal regeneratyion in Nogo-deficient mice. Neuron.

Inman, D., and Steward, O. (provisionally accepted pending revision) Absence of long tract regeneration into the connective tissue matrix that forms at the site of a spinal cord injury in mice. J. Comp. Neurol.

Oishi, Y., Baratta, J., and Steward, O. (submitted) Assessment of factors regulating corticospinal axon growth using cortex/spinal cord organotypic co-cultures: effects of age and neurotrophic factors

Sullivan, P., Shuttleworth, C., Jonas, E., Sharp, K., Thompson, L., Kaczmarek, L., Connor, J., Steward, O. (submitted) Intrinsic differences in mitochondria determine strain differences in sensitivity to excitotoxic neurodegeneration in inbred strains of mice.

Ogoshi, F. Yin, H.Z., Kuppumbatti, Y., Song, B, Amindari, S., Weiss, J.H. Tumor-necrosis-factor-alpha (TNF-α) induces rapid insertion of Ca2+-permeable α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp. Neurol. 193, 384-393 (2005).

Aimone J. B., Leasure J. L., Perreau V. M., Thallmair M., Anderson, A.J., Arvanian V. L., Bareyre F. M., Bunge M. B., Cotman C. W., Craveiro L., Crown E. D., Edgerton V. R., Cesar C., Gage F. H., Garcia A. J., Garraway S. M., Horner P. J., Howley S,, Ichiyama R. M., Mendell L. M., Moon L. D. F., Moore L., Parada L. F., Pearse D. M., Petruska J. C., Romero M I., Schnell L., Schwab M. E., Tansey K. E., Thuret S. Spatial and temporal gene expression profiling of the contused rat spinal cord. 2004. Experimental Neurology. 189(2): 204-221.

Anderson A. J., Robert S., Huang W., Young W. and Cotman C. W. Activation of complement pathways after contusion-induced spinal cord injury. 2004. Journal of Neurotrauma. 21(12): 1831-1836.

Steward, O. Zheng, B, Ho, C, Anderson, KD, Tessier-Lavigne, M. (2004). The dorsolateral corticospinal tract in mice: An alternative route for corticospinal input to caudal segments following dorsal column lesions. J. Comp. Neurol. 472:463-477.

Anderson, KDD, Abdul, M, Steward, O. (2004). Quantitative assessment of deficits and recovery of forelimb motor function after cervical spinal cord injury in mice. Exp. Neurol. 190:184-191.

Anderson, KDD. (2004). Targeting recovery: Priorities of the spinal cord injured population. J. Neurotrauma. 21:1371-1383.

Glaser J, Gonzalez R, Perreau VM, Cotman CW, Keirstead HS. (2004) Neutralization of the chemokine CXCL 10 enhances tissue sparing and angiogenesis following spinal cord injury. J Neurosci Res. Sep 1; 77(5):701-8.

Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenberg BA, Cotman CW, Milgram NW, Su MY. (2004) Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. Sep 22; 24(38):8205-13.

Tong L, Balazs R, Thornton PL, Cotman CW.(2004) -Amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. The Journal of Neuroscience. Jul; 24(30):6799-6809.

Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW.(2004) Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J CLin Invest. Jul; 114(1):121-30.

Adlard, PA., and Cotman, CW. (2004). Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression. Neuroscience, 124(4): 985-92.

Cramer SC, Rordorf G, Maki JH, Kramer LA, Grotta JC; Burgin WS, Hinchey JA, Benesch C, Furie KL, Lutsep HL, Kelly E, Longstreth WT, Jr. Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study. Stroke 2004; 35:46-50.

Nhan H, Barquist K, Bell K, Esselman P, Odderson IR, Cramer SC. Brain function early after stroke in relation to subsequent recovery. Journal of Cerebral Blood Flow and Metabolism 2004; 24:756-763.

Kramár, E.A., B. Lin, C-Y Lin, A. Arai, C. M. Gall, and G. Lynch 2004 A novel mechanism for the facilitation of theta-induced LTP by brain derived neurotrophic factor. J. Neurosci. 24: 5151-5161.

Gall, C.M. and G. Lynch 2004 Integrins, Synaptic Plasticity and Epileptogenesis. In: Recent Advances in Epilepsy Research, Advances: Molecular Mechanisms f Epileptogenesis (H. Scarfman and D.K. Binder, Eds.). Adv. Exp. Med. Biol. Vol. 548, pp. 12-33. Kluver Academic.

Colgin, L.L., D. Kubota, F.A. Brucher, Y. Jia, E. Branyan, C.M. Gall and G. Lynch 2004 Spontaneous waves in the dentate gyrus of ventral hippocampal slices. J. Neurophysiol. 92:3385-98.

Poulsen, F.R., J. C. Lauterborn, J. Zimmer, and C.M. Gall 2004 Differential expression of BDNF transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. Neurosci.. 126: 665-676.

Janette Glaser, Rafael Gonzalez, Victoria Perreau, Carl W. Cotman and Hans S. Keirstead (2004) Neutralization of the Chemokine CXCL10 Enhances Tissue Sparing and Angiogenesis Following Spinal Cord Injury. J. Neurosci. Res. 77: 701-708.

Minodora O. Totoiu, Gabriel I. Nistor, Thomas E. Lane and Hans S. Keirstead (2004) Remyelination, Axonal Sparing and Locomotor Recovery Following Transplantation into a Demyelinated Neurodegenerative Disease State. Exp. Neurol. 187: 254-265 (journal cover).

Roya Azanchi, Giovanna Bernal, Ranjan Gupta and Hans S. Keirstead (2004) Combined demyelination plus Schwann cell transplantation therapy increases spread of cells and axonal regeneration following contusion injury. J. Neurotrauma 21:775-88.

Stutzmann, G. E., LaFerla, F. M., Parker, I. (2004). Dysregulated IP3- signaling in cortical neurons of knock-in mice expressing an Alzheimer's linked mutation in presenilin-1 result in exaggerated Ca2+ signals and altered membrane excitability. J. Neurosci. 24, 508-513.

Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., and LaFerla, F. M. (2004). Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43, 321-332.

Rissman, R. A., Poon, W. W., Blurton-Jones, M., Oddo, S., Torp, R., LaFerla, F. M., Rohn, T. T., and Cotman, C. W. (2004). Caspase-cleavage of tau is an early event in neurofibrillary pathology in Alzheimer's disease. J. Clin. Invest. 114, 121-130.

Akbari, Y., Hitt, B., Murphy, M. P., Dagher, N. N., Tseng, B. P., Green, K. N., Golde, T. E., and LaFerla, F. M. (2004). Presenilin regulates capacitative calcium entry dependently and independently of γ-secretase activity. BBRC 322, 1145-1152.

Ohanam, E., Segal, D., Palty, R., Ton-That, D., Moran, A., Sensi, S.L., Weiss, J.H., Hershfinkel, M., Sekler, I. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 279(6):4278-84 (2004).

Rao S.D. & Weiss, J.H. Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis. Trends Neurosci. 27 (1) 17-23 (2004).

Zhou M., Cribbs D. H., Anderson A. J., Cummings B. J., Su J. H., Wasserman A. J., and Cotman C. W. The induction of the TNFa death domain signaling pathway in Alzheimer's Disease brain. 2003. Neurochemical Research. 28(2) 307-318.

Anderson A. J., Su J. H., Cribbs D. H., Kesslak P., and Cotman C. W. Fas death receptor pathway upregulation following Aβ administration in cultured neurons and in association with Aβ deposition in AD brain: a mechanism for increased neuronal vulnerability. 2003. Neurobiology of Disease. 12:182-193.

Anderson, KDD, Merhege, MA, Morin, M, Bolognani, F, Perrone-Bizzozero, NI. (2003). Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regeneration. Exp. Neurol. 183:100-108.

Tapp, P.D., Siwak, C.T., Estrada, J., Head, E., Muggenburg, B.A., Cotman, C.W., and Milgram, N.W. (2003). Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learning and Memory, 10(1): 64-73.

Head, E., Lott, I.T., Hof, P.R., Bouras, C., Su, J.H., Kim, R., Haier, R., and Cotman, C.W. (2003). Compensatory and pathological events associated with tau pathology in middle-aged individuals with Down syndrome. Journal of Neuropathology and Experimental Neurology, 62(9): 917-926.

Zhao, M., Su, J., Head, E., and Cotman, C.W. (2003). Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiology of Disease, 14(3): 391-403.

Kayed, R., Head, E., Thompson, J.L., McIntire, T.M., Milton, S.C., Cotman, C.W., Glabe, C.G. (2003). Common structure of soluble amyloid oligomers implies common mechanism of pathogenisis. Science, 18(300): 486-489.

Su, J.H., Anderson, A.J., Cribbs, D.H., Tu, C., Tong, L., Kesslak, P.J., Cotman, C.W. (2003). Fas and Fas ligand are associated with neuritic apoptosis in the AD brain and participate in B-Amyloid-induced neuronal death. Neurobiology of Disease, 12:182-193.

Zhao, M., Cribbs, D.H., Anderson, A.J., Cummings, B.J., Su, J.H., Wasserman, A.J., Cotman, C.W. (2003). The induction of the TNF death domain signaling pathway in Alzheimer's disease brain. Neurochem. Research, 28(2):307-318.

Garcia, C., Chen, M.J., Garza, A.A., Cotman, C.W. Russo-Neustadt, A. (2003). The influence of specific noradrenergic and serotonergic lesions on the expression hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience, 119(3): 721-32.

Cramer SC, Maki JH, Waitches GM, D'Souza N, Grotta JC, Burgin WS, Kramer LA. Paradoxical emboli from calf and pelvic veins in cryptogenic stroke. Journal of Neuroimaging 2003; 13:218-223.

Crafton KR, Mark AN, Cramer SC. Improved understanding of motor cortex injury by incorporating measures of functional anatomy. Brain 2003; 126:1650-1659.

Aylward EH, Richards TL, Berninger VW, Nagy WE, Field KM, Grimme AC, Richards AL, Thomson JB, Cramer SC. Effects of instructional treatment on brain activation for specific language processes in children with dyslexia. Neurology 2003; 61:212-219.

Cramer SC, Benson RR, Burra VC, Himes D, Crafton KR, Janowsky JS, Brown JA, Lutsep HL. Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studies. Neurological Research 2003; 25:811-814.

Brown JA, Lutsep H, Cramer SC, Weinand M. Motor cortex stimulation for enhancement of recovery after stroke: Case report. Neurological Research 2003; 25:815-818.

Duel, BP, Steinberg-Epstein, R, Hill, MA and Lerner, M: A Survey of Dysfunctional Voiding in Children with Attention Deficit-Hyperactivity Disorder, J. Urol. 170(5), 1521-4, 2003

Hess, U.S., S.P. Whalen, L.M. Sandoval, G. Lynch, and C.M. Gall 2003 Positive modulators of AMPA-type glutamate receptors suppress dopamine-driven rotation behavior: Implications for treatment of Schizophrenia. Neuroscience 121: 509-521.

Kramar, E.A., J. A. Bernard, C. M. Gall, and G. Lynch 2003 Integrins modulate fast excitatory transmission at hippocampal synapses. J. Biol. Chem. 278: 10722-10730.

Gall, C.M., J.K. Pinkstaff, J.C. Lauterborn, Y. Xie and G. Lynch 2003 Integrins regulate neuronal neurotrophin gene expression through effects on voltage sensitive calcium channels. Neuroscience 188: 925-940.

Colgin, L. L., E. A. Kramar, C. M. Gall and G. Lynch 2003 Septal modulation of excitatory transmission in hippocampus. J. Neurophysiol. 90: 2358-2366.

Lauterborn, J.C., G.S. Troung and C.M. Gall 2003 Intermittant ampakine treatment sustains elevated hippocampal brain derived neurotrophic factor levels in vitro. JPET : 307: 297-305.

Lin, B., A. C. Arai, G. Lynch, and C. M. Gall 2003 Integrins regulate NMDA receptor-mediated synaptic currents. J. Neurophysiol. 89(5): 2874-2878.

Rafael Gonzalez, Janette Glaser, Michael T. Liu, Thomas E. Lane and Hans S. Keirstead (2003) Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury Exp Neurol. 184: 456-463.

Binhai Zheng, Hans Keirstead, Oswald Steward, Marc Tessier-Lavigne (2003) Lack of Extensive Spinal Regeneration in Nogo-deficient mice Neuron. 38:1-20

Stutzmann, G. E., LaFerla, F. M., and Parker, I. (2003). Calcium signaling in mouse cortical neurons studies by 2-photon imaging and photoreleased IP3. J. Neurosci. 23, 758-765.

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T.E., Metherate, R., Mattson, M. P., Akbari, Y., and LaFerla, F. M. (2003). Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron 39, 409-421.

Inman, D., Guth, L. and Steward, O. (2003). Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord. J. Neurotrauma, 20, 33-42.

Rao SD., Yin, HZ, and Weiss, JH. Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. The Journal of Neuroscience, 23: 2627-2633 (2003).

Sensi, S.L., Ton-That, D., Sullivan, P.G., Jonas, E.A., Gee, K.R., Kaczmarek, L.K. and Weiss, J.H. Modulation of mitochondrial function by endogenous Zn2+ pools, Proc. Natl. Acad. Sci. (USA) 100:6157-62 (2003).

Sensi, S.L., Ton-That, D., Weiss, J.H., Rothe, A. and Gee, K.R. A new mitochondrial fluorescent zinc sensor, Cell Calcium 34, 281-284 (2003).

Cummings B. J., Mason, A. J. L., Kim R. C., Sheu P. C-Y., and Anderson A. J. Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imaging. 2002. Neurobiology of Aging 23:161-170

Anderson, A. J. Mechanisms and pathways of inflammatory responses in CNS trauma: Spinal cord injury. Journal of Spinal Cord Medicine. 2002. 25(2):70-9.

Berchtold, N.C., and Cotman, C.W. (2002). Exercise: A behavioral intervention to enhance brain health and plasticity. Trends in Neuroscience, 25(6), June.

Cotman, C.W., and Engesser-Cesar, C. (2002). Exercise enhances and protects brain function. Exerc Sport Sci Rev., 30(2): 75-9.

Cotman, C.W., Head, E., Muggenburg, B.A., Zicker, S., and Milgram, N.W. (2002). Brain aging in the canine: A diet enriched in antioxidants reduces cognitive dysfunction. Neurobiology of Aging, 23: 809-818.

Cramer SC, Mark A, Barquist K, Nhan H, Stegbauer KC, Price R, Bell K, Odderson I, Esselman P, Maravilla KR. Motor cortex activation is preserved in patients with chronic hemiplegic stroke. Annals of Neurology 2002; 52:607-616..

Schaechter JD, Kraft, E, Hilliard TS, Dijkhuizen RM, Benner T, Finklestein SP, Rosen BR,

Cramer SC. Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study. Neurorehabilitation and Neural Repair 2002; 16:326-338.

Bi, X., J. Zhou, C.M. Gall and G. Lynch 2002 Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 112: 827-840.

Kramár, E.A., J.A. Bernard, C.M. Gall and G. Lynch. 2002 Alpha3 Integrin Receptors Contribute to the Consolidation of Long Term Potentiation. Neuroscience: 110:29-39.

Kusske, JA. Managed Care Gives Way to Defined Self-Pay. Are Rising Costs Pricing Health Out of the Market? AANS Bulletin 11(1): 15, 15, 2002.

Kusske, JA. Neurosurgical Practice in the Current Regulatory Environment. Neurosurg. Focus, Vol 12, April, 2002.

Kusske, JA. EMTALA: The On-Call Neurosurgeon's Responsibility (The second of a series). California Association of Neurological Surgeons Newsletter Vol 29, No. 1, April 2002.

Kusske, J.A. Privacy Rules: Second HIPAA "Administrative Simplification" Compliance Date Nears. AANS Bulletin 11(3): 20, Fall, 2002.

Kusske, J.A. The HIPAA Train is Here: Getting on Board Now May Benefit Your Practice. AANS Bulletin 11(2): 30, Summer, 2002.

Sugarman, M. S., Yamasaki, T. T., Oddo, S., Echegoyen, J. C., Murphy, M. P., Leissring, M. A., and LaFerla, F.M. (2002). Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle. Proc. Natl. Acad. Sci., U.S.A. 99, 6334-6339.

Leissring, M. A., Murphy, M. P., Mead, T. R., Akbari, Y., Sugarman, M. C., Jannatipour, M., Anliker, B., Müller, U.,Saftig, P., De Strooper, B., Wolfe, M. S., Golde, T. E., and LaFerla, F. M. (2002). A physiologic signaling role for the. γ-secretase-derived intracellular fragment of APP. Proc. Natl. Acad. Sci., U.S.A., 99 4697-4702.

LaFerla, F. M. (2002). Calcium dyshomeostasis and intracellular signaling in Alzheimer's disease. Nature Reviews Neuroscience 3, 862-872.

Jiang, D., Sulllivan, P.G., Sensi, S.L., Steward, O., and Weiss, J.H. (2002) Zn2 increases permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. J. Biol. Chem. 276, 47524-47529.

Temple, M.D., Kosik, K.S., and Steward, O. (2002) Spatial learning is preserved in rats after early development in a microgravity environment. Neurobiol. of Learning and Memory 78, 199-216.

Inman, D., Guth, L. and Steward, O. Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J. Comp. Neurol., 451, 225-235.

Sensi, S.L., Dien Ton-That, D. and Weiss J.H. Mitochondrial sequestration and Ca2+ dependent release of cytosolic Zn2+ loads in cortical neurons. Neurobiol. Dis. 10, 100-108 (2002).

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Su J. H., Zhao M., Anderson A. J., Srinivasan A., and Cotman C. Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. 2001. Brain Research 828(2) 350-357.

Satou T., Anderson A. J., Itoh T., Tamai Y., Ohde H., and Hashimoto S. Repetitive administration of tetrabenazine induces irreversible changes in locomotion and morphology of the substantia nigra in rats. 2001. Experimental Toxic Pathology 53: 303-308.

Cotman C. W., Tong L., Anderson A. J., Cribbs D. H., and Su J. H. β-amyloid toxicity: diverse biological activities drive multiple cellular mechanisms. 2001. In: Alzheimer's Disease: Advances in etiology, pathogenesis, and therapeutics. Pp 407-420. K. Iqbal, S. S. Sisodia, and B. Winblad. John Wiley & Sons, New York, NY.

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Cramer SC, Fray E, Tievsky A, Parker RA, Riskind PN, Stein, MC, Wedeen, V, Rosen BR. Changes in motor cortex activation after recovery from spinal cord inflammation. Multiple Sclerosis, 2001; 7:364-370.

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Shanberg, AM, Sanderson, K, Duel BP: Reoperative hypospadias repair using the Snodgrass incised-plate urethroplasty. BJU Int, 87(6), 544-7, 2001

Chun, D., C.M. Gall, X. Bi and G. Lynch 2001 Evidence that integrins contribute to multiple stages in the consolidation of long term potentiation. Neuroscience 105: 815-829.

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Kusske, JA. The Harm of Economic Credentialing: Hospitals Tempted to Use Financial Data to Select Staff. AANS Bulletin 10(2):18, 2001.

Kusske, JA. EMTALA: Where We Stand: GAO Unable to Measure Overall Impact. AANS Bulletin 10(3): 22, 2001.

Kusske, JA.and Orrico, K. EMTALA. How Can Neurosurgeons Comply? AANS Bulletin 10(4): 7-12, 2001.

Kusske, JA. EMTALA: The On-Call Neurosurgeon's Responsibility (The first of a series). California Association of Neurological Surgeons Newsletter Vol 28, No. 2, November, 2001.

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Denslow, M.J., Eid, T., Du, F., Schwarcz, R., Lothman, E.W, and Steward, O. (2001). Disruption of inhibition in area CA1 of the hippocampus in a rat model of temporal lobe epilepsy. J. Neurophysiol., 86, 2231-2245.

Villanueva, S., and Steward, O. (2001) Glycoprotein synthesis at the synapse: fractionation of polypeptides synthesized within isolated dendritic fragments by concanavalin A chromatography. Mol. Brain Res. 91, 137-147.

Jiang, D., Sullivan, P.G., Sensi, S.L., Steward, O. and Weiss, J.H. Zn2+ induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. J. Biol. Chem. 276, 47524-47529 (2001).

Cotman C. W. and Anderson A. J. The brain's microenvironment, early functional loss, and the conversion to Alzheimer disease. 2000. Annals of the National Academy of Sciences. 924:112-16

Anderson A. J., Ruehl W. W., Fleischmann L. K., Stenstrom K., Entriken T. L., and Cummings B. J. DNA damage in the aged canine brain: correlation with Aβ deposition. 2000. Progress in Neuropsychopharmacology and Biological Psychiatry 24: 787-799.

Anderson A. J., Stoltzner S., Lai F. and Nixon R. A. Morhological and biochemical assessment of DNA damage and apoptosis in Down's syndrome and Alzheimer's disease, and the effect of postmortem tissue archival on TUNEL. 2000. Neurobiology of Aging 24(4):511-524.

Satou T., Itoh T., Tamai Y., Ohde H., Anderson A. J., and Hashimoto S. Neurotrophic effects of FPF-1070 on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks. 2000. Journal of Neurotransmission 107(11): 1253-1262.

Cotman C. W., Qian H., Ivins K., and Anderson A. J. Cellular signaling pathways in neuronal apoptosis: role in neurodegeneration and Alzheimer's disease. 2000. In: Cerebral signal transduction: From first to fourth messengers. Ed. M. E. A. Reith. Humana Press. Humana Press, Totowa, NJ.

Cotman C. W. and Anderson A. J. Selective vulnerability of the brain to Alzheimer pathology. 2000. In: Neurodegenerative Dementias. pp 127-131. Ed. C. M. Clark and J. Q. Trojanowski. McGraw-Hill.

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Kusske, JA.and McNett, CL. EMTALA Update. OIG steps up enforcement and targets physicians. AANS Bulletin 9(1): 18, 2000.

Kusske, JA. Physicians Under Fire. Waging War on Fraud and Abuse. AANS Bulletin 9 (2): 5-7, 2000.

Kusske, JA. Pressure on Not-for-Profits. Hospitals face tough financial future. AANS Bulletin 9(3):26-27, 2000.

Kusske, JA. Task Force Postmortem. Study suggests ways to cut practice costs. AANS Bulletin 9(4):20, 2000.

Cribbs, D. H., Azizeh, B. A., Cotman, C. W., & LaFerla, F. M. (2000). Fibril formation and neurotoxicity by a herpes simplex virus glycoprotein B fragment with homology to the Alzheimer's β-amyloid peptide. Biochemistry 39, 5988-5994.

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Schauwecker, P.E., Ramirez, J.J., Steward, O. (2000) Genetic dissection of the signals that induce synaptic reorganization. Exp. Neurol., 161:139-52.

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