The focus of the laboratory is to evaluate underlying molecular and cellular mechanisms contributing to neuroinflammation, neurodegeneration, and repair in preclinical models of neurologic disease.
Tom Lane has been working in evaluating mechanisms governing neuroinflammation in response to infection, injury, or autoimmune-induced neurologic disease.
Additionally, the Lane laboratory is working to define mechanisms associated with host defense and disease following infection of the central nervous system (CNS) with neuroadapted strains of murine coronaviruses (MuCoV) which induces an acute encephalomyelitis followed by a chronic immune-mediated demyelinating disease that has similar clinical and histologic disease to MS. More recently, Dr. Lane’s laboratory is exploring how infection of susceptible transgenic mice expressing the human angiotensin converting enzyme 2 (hACE2) which is the receptor for SARS-CoV-2 which is the causative agent for COVID-19. We are currently exploring mechanisms by which SARS-CoV-2 infection leads to neurologic disease by either directly infecting the CNS or through induction of an acute cytokine/chemokine storm. Furthermore, there is ongoing testing of anti-viral drugs that inhibit SARS-CoV-2 replication in vitro and in vivo.